| 货号 | 3572/50 |
| 别名 | 2-Cyclopentyl-4-(5-phenyl-1H-pyrrol |
| 供应商 | Tocris |
| 生物活性 | Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 382.45 |
| 分子式 | C25H22N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 890842-28-1 |
| 参考文献 | Hallet al (2012) Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. Breast Cancer Res.Treat 135 469. PMID: 22842983. Sherket al (2008) Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 68 7475. PMID: 18794135. |