| 货号 | 4026/50 |
| 别名 | 5-[[4-(4-Pyridinyl)-6-quinolinyl]me |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of PI 3-kinase α(PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 333.36 |
| 分子式 | C18H11N3O2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Knightet al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 139. Saadiaet al (2009) Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 15 3029. PMID: 19383818. |