| 货号 | 2563/50 |
| 别名 | 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dim |
| 供应商 | Tocris |
| 生物活性 | Potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 496.64 |
| 分子式 | C32H36N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 574013-66-4 |
| 参考文献 | Pellicciariet al (2006) Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 49 4208. PMID: 16821780. Downeset al (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 11 1079. PMID: 12718892. Nicolaouet al (2003) Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 1 908. PMID: 12929628. |