| 货号 | 3705/50 |
| 别名 | (E/Z)-4-[1-[4-[2-(Methylamino)ethox |
| 供应商 | Tocris |
| 生物活性 | Estrogen receptor α(ERα) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 373.49 |
| 分子式 | C25H27NO2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Wuet al (2011) Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 13 R27. PMID: 21392396. Wuet al (2009) The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor a for degradation in breast cancer cells. Cancer Res. 69 1722. PMID: 19244106. Limet al (2006) Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J.Pharmacol.Exp.Ther. 318 503. PMID: 16690721. |