| 货号 | 1849/50 |
| 别名 | 2-Butyl-3,4-dihydro-N,N-dimethyl-4- |
| 供应商 | Tocris |
| 生物活性 | Highly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively). Potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 547.05 |
| 分子式 | C28H30N8O2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 187683-79-0 |
| 参考文献 | Mederskiet al (1995) 4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor. Bioorg.Med.Chem.Lett. 52665. Mederskiet al (1994) Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives. J.Med.Chem. 37 1632. PMID: 8201597. |