| 货号 | 2688/50 |
| 别名 | (4S)-4,11-Diethyl-3,4,12,14-tetrahy |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 623.14 |
| 分子式 | C33H38N4O6.HCl |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO |
| CAS号 | 100286-90-6 |
| 参考文献 | Mortonet al (2005) Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice. Can.Chemother.Pharmacol. 56629. Vassalet al (1996) Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br.J.Cancer. 74 537. PMID: 8761367. Kawatoet al (1993) Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. J.Pharm.Pharmacol. 45 444. PMID: 8099964. |