| 货号 | 2779/50 |
| 别名 | N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4 |
| 供应商 | Tocris |
| 生物活性 | Selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 400.99 |
| 分子式 | C23H32N4.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 157286-86-7 |
| 参考文献 | Hodgsonet al (2007) Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol.Biochem.Behav. 86 431. PMID: 17291571. Lundkistet al (1996) A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur.J.Pharmacol. 309 195. PMID: 8874139. Schulzet al (1996) CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc.Natl.Acad.Sci.USA 9310477. |