CHMFL-FLT3-122 ( )
货号：
5800/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 5800/50 |
| 别名 | 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-(dimethylamino)-ethanone |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective FLT3 inhibitor (IC50 = 40 nM). Exhibits >10-fold and 170-fold selectivity for FLT3 over BTK kinase and c-KIT kinase, respectively in vitro. Induces apoptosis by arresting cell cycle in G0/G1phasein vitro. Suppresses tumor growth in an AML xenograft model. Modestly orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 471.55 |
| 分子式 | C26H29N7O2 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO |
| 参考文献 | Liet al (2015) Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. J.Med.Chem. 58 9625. PMID: 26630553. |
