| 货号 | 2199/50 |
| 别名 | N-[[trans-4-[[(4-Amino-2-quinazolin |
| 供应商 | Tocris |
| 生物活性 | Extremely selective, non-peptide NPY Y5 receptor antagonist. Displays > 1000-fold selectivity over Y1, Y2 and Y4 receptors; IC50 values are 1.4, 2765, 7187 and 5637 nM at cloned rat Y5, Y1, Y2 and Y4 receptors respectively. Potently inhibits NPY-induced food intake following i.p. administration in diabetic, free-feeding and fasted rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 512.07 |
| 分子式 | C26H29N5O2S.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 192322-50-2 |
| 参考文献 | Lecklinet al (2002) Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029. PMID: 11959807. Dumontet al (2000) Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5). Can.J.Physiol.Pharmacol. 78 116. PMID: 10737674. Criscioneet al (1998) Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J.Clin.Invest. 102 2136. PMID: 9854049. |