| 货号 | 2731/50 |
| 别名 | N3-(4-Fluorophenyl)-1H-pyrazolo-[3, |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 244.23 |
| 分子式 | C11H9FN6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 522629-08-9 |
| 参考文献 | Andersson and Sundler (2006) Posttranscriptional regulation of TNFα expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages. Cytokine 33 52. PMID: 16431125. Ishidaet al (2003) Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells. Circ.Res. 93 1218. PMID: 14605021. Knaufet al (2001) Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. Mol.Cell.Biol. 21 5500. PMID: 11463832. |