| 货号 | 4179/50 |
| 别名 | N-[[4-(1,4,8,11-Tetraazacyclotetrad |
| 供应商 | Tocris |
| 生物活性 | Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 896.07 |
| 分子式 | C24H38N6.6HBr |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 25 mM in DMSO |
| 参考文献 | Bodartet al (2009) Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4. Biochem.Pharmacol. 78 993. PMID: 19540208. Rosenkildeet al (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J.Biol.Chem. 282 27354. PMID: 17599916. |