| 货号 | 1111/50 |
| 别名 | (1S,3R,4S)-1-Aminocyclopentane-1,3, |
| 供应商 | Tocris |
| 生物活性 | Agonist for group III mGlu receptors (EC50 values are 7.2 and 8.2 μM for mGlu4a and mGlu8 respectively). Anticonvulsant in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 217.18 |
| 分子式 | C8H11NO6 |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH |
| 参考文献 | Chapmanet al (2001) Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur.J.Pharmacol. 424 107. PMID: 11476756. De Colleet al (2000) Pharmacological characterization of the rat metabotropic glutamate receptor 8a revealed strong similarities and slight differences with the type 4a receptor. Eur.J.Pharmacol. 394 17. PMID: 10771029. Acheret al (1997) Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J.Med.Chem. 40 3119. PMID: 9301676. |