| 货号 | 3369/50 |
| 别名 | (2E)-2-[1-(3-Bromophenyl)ethylidene |
| 供应商 | Tocris |
| 生物活性 | Potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca2+mobilizationin vitro(pEC50 values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 518.36 |
| 分子式 | C25H20BrN5O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 916170-19-9 |
| 参考文献 | Gardellet al (2008) Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther. 327 799. PMID: 18768780. Seitzberget al (2008) Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem. 51 5490. PMID: 18720984. |