| 货号 | 1701/50 |
| 别名 | (1R-cis)-1-(Aminomethyl)-3,4-dihydr |
| 供应商 | Tocris |
| 生物活性 | Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 365.9 |
| 分子式 | C20H27NO3.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 145307-34-2 |
| 参考文献 | Lewiset al (1998) Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. J.Pharmacol.Exp.Ther. 286 345. PMID: 9655879. Acquaset al (1994) The potent and selective dopamine D1 receptor agonist A-77636 increases cortical and hippocampal acetylcholine release in the rat. Eur.J.Pharmacol. 260 85. PMID: 7957630. Kebabianet al (1992) A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. Eur.J.Pharmacol. 229 203. PMID: 1362704. |