A 582941 (50 MG)
货号：
4341/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 4341/50 |
| 别名 | Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole |
性能| 供应商 | Tocris |
| 生物活性 | Selectiveα7 nAChR partial agonist; exhibits high affinity for both rat and human α7 receptors (Ki values are 10.8 and 16.7 nM respectively). Displays ~15-fold selectivity for α7 over 5-HT3 receptors (Ki = 150 nM for 5-HT3). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 280.37 |
| 分子式 | C17H20N4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| 参考文献 | Andersonet al (2008) [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity α7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. J.Pharmacol.Exp.Ther. 324 179. PMID: 17959745. |
