| 货号 | 4697/50 |
| 别名 | 4'-[3-[(3R)-3-(Dimethylamino)-1-pyrr |
| 供应商 | Tocris |
| 生物活性 | High affinity histamine H3 receptor antagonist (Ki values are 21.7 and 22.7 nM for rat and human H3 receptors, respectively). Exhibits selectivity for human H3 over H1, H2 and H4 receptors (Ki values are 2940, 14400 and >10000 nM respectively). Shown to reduce weight in a diet-induced obesity model. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 422.39 |
| 分子式 | C22H27N3O.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 20 mM in DMSO |
| 参考文献 | Hancocket al (2004) Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. Eur.J.Pharmacol. 487 183. PMID: 15033391. Hancocket al(2004)In vitro optimization of structure activity relationships by analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists. Basic Clin.Pharmacol.Toxicol. 95 144. PMID: 15447739. |