| 货号 | 4436/50 |
| 别名 | 6-Amino-8-chloropurine riboside |
| 供应商 | Tocris |
| 生物活性 | Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 301.69 |
| 分子式 | C10H12ClN5O4 |
| 可溶性/溶解性 | Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Cervantes-Gomezet al (2011) ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells. J.Pharmacol.Exp.Ther. 339 545. PMID: 21821695. Guet al (2006) 8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells Biochem.Pharmacol. 72 541. PMID: 16844099. Zhanget al (2004) Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 6 802. PMID: 15720807. |