4E1RCat (50 MG)
货号：
4215/50 基本售价：
12274.1 元 规格：
50 mg
产品信息
概述| 货号 | 4215/50 |
| 别名 | 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid |
性能| 供应商 | Tocris |
| 生物活性 | Inhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50~4μM). Exhibits chemosensitizing properties. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 478.45 |
| 分子式 | C28H18N2O6 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Cencicet al (2010) Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc.Natl.Acad.Sci.USA 1081046. |
