| 货号 | 4125/50 |
| 别名 | (1R,5S)-1,2,3,4,5,6-Hexahydro-9-(3- |
| 供应商 | Tocris |
| 生物活性 | High affinity α4β2 partial agonist (Ki values are 0.91, 119 and 1100 nM for α4β2,α3β4 and α7 receptors respectively). Shows little activity at α3β4 and α7 receptors. Exhibits antidepressant-like effects in mouse models of antidepressant efficacy. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 267.33 |
| 分子式 | C16H17N3O |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Papkeet al (2011) Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists. J.Pharmacol.Exp.Ther. 3371. Papkeet al (2010) Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 333 501. PMID: 20100906. Mineuret al (2009) Cytisine-based nicotinic partial agonists as novel antidepressant compounds. J.Pharmacol.Exp.Ther. 329 377. PMID: 19164465. |