GNE-495
货号：
21808-25mg 基本售价：
12250.0 元 规格：
25 mg
产品信息
概述| 货号 | 21808-25mg |
| 描述 | GNE-495 is an orally bioavailable, potent, and selective MAP4K4 inhibitor (IC50 = 3.7 nM).1 In cell sprouting assays, it increases the number of protrusions.2 In a mouse model of oxygen-induced retinopathy, GNE-495 normalizes the percentage of pathological vessels and hemorrhagic areas. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ndubako, C.O.,Crawford, T.D.,Chen, H., et al. Structure-based design of GNE-495, a potent and selective MAP4K4 inhibitor with efficacy in retinal angiogenesis. ACS Med. Chem. Lett. 6(8), 913-918 (2015).
2.Vitorino, O.,Yeung, S.,Crow, A., et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature 519(7544), 425-430 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 405.4 |
| 分子式 | C22H20FN5O2 |
| CAS号 | 1449277-10-4 |
| 稳定性 | ≥ 2 years |
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