| 货号 | 9002040-50mg |
| 描述 | Enniatin complex is a mixture of cyclohexadepsipeptides, commonly isolated from fungi, that act as ionophores, forming pores in cellular membranes to allow selective ion transport.1,2 The complex typically contains the major components: A 17456, A1 17457, B (Item No. 15382), and B1 17245 together with minor amounts of enniatin C, D, E, and F.1 Enniatins exhibit antimicrobial activity against a variety of eukaryotic and prokaryotic genera, inhibit acyl-CoA:cholesterol acyltranferase, and induce apoptosis in several cancer lines.1,3,4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sy-Cordero, A.A.,Pearce, C.J., and Oberlies, N.H. Revisiting the enniatins: A review of their isolation, biosynthesis, structure determination and biological activities. J.Antibiot.(Tokyo) 65(11), 541-549 (2012). 2.Kamyar, M.R.,Rawnduzi, P.,Studenik, C.R., et al. Investigation of the electrophysiological properties of enniatins. Archives of Biochemistry and Biophysics 429(2), 215-223 (2004). 3.Tomoda, H.,Huang, X.H.,Cao, J., et al. Inhibition of acyl-CoA: Cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J.Antibiot.(Tokyo) 45(10), 1626-1632 (1992). 4.Wätjen, W.,Debbab, A.,Hohlfeld, A., et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol.Nutr.Food Res. 53(4), 431-440 (2009). 5.Dornetshuber, R.,Heffeter, P.,Kamyar, M.R., et al. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Chemical Research in Toxicology 20(3), 465-473 (2007). 6.Hiraga, K.,Yamamoto, S.,Fukuda, H., et al. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 328(4), 1119-1125 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 639.8 |
| 分子式 | C33H57N3O9 (for B) |
| CAS号 | 11113-62-5 |
| 稳定性 | ≥ 2 years |
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