| 货号 | 16380-1mg |
| 描述 | 8-iso-13,14-dihydro-15-keto Prostaglandin F2α(8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-isoPGF2α), in rabbits, monkeys and humans.18-isoPGF2α is a PG-like product of non-specific lipid peroxidation.2 In both humans and monkeys, exogenously infused 8-isoprostane is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.1 A similar pattern is observed when tritiated 8-isoprostane is infused into rabbits.3 Early in the infusion (within 10 minutes) 8-iso-13,14-dihydro-15-keto PGF2α was a significant component of the metabolite profile, which was comprised mostly of dinor 8-isoprostane metabolites. 8-iso-13,14-dihydro-15-keto PGF2α weakly inhibits the U-46619 or collagen-induced aggregation of human platelets, although a number of the E-series isoprostanes are much more potent in this assay.4 |
| 别名 | 8-iso-13,14-dihydro-15-keto PGF2α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chiabrando, C.,Valagussa, A.,Rivalta, C., et al. Identification and measurement of endogenous β-oxidation metabolites of 8-epi-prostaglandin F2α. The Journal of Biological Chemisty 274, 1313-1319 (1999). 2.Morrow, J.D.,Hill, K.E.,Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proceedings of the National Academy of Sciences of the United States of America 87, 9383-9387 (1990). 3.Basu, S. Metabolism of 8-iso-prostaglandin F2α. FEBS Letters 428, 32-36 (1998). 4.Cranshaw, J.H.,Evans, T.W. and Mitchell, J.A. Charcterization of the effects of isoprostanes on platelet aggregation in human whole blood. British Journal of Pharmacology 132, 1699-1706 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 354.5 |
| 分子式 | C20H34O5 |
| CAS号 | 191919-02-5 |
| 稳定性 | ≥ 1 year |
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