| 货号 | 9001737-25mg |
| 描述 | Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.1 This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.2 Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. Autoinducers containing a phenylacetanoyl group in the acyl chain display a wide range of inhibitory and activating effects on various R protein transcriptional regulators.3,4,5 N-phenylacetyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing in the model symbiont V. fischeri and the pathogens A. tumefaciensandP. aeruginosa.5,6 It has been reported to antagonize TraR signaling in A. tumefaciens, LasR signaling in E. coli, and LuxR signaling in V. fischeri.4 |
| 别名 | C8-HSL; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.González, J.E. and Keshavan, N.D. Messing with bacterial quorum sensing. Microbiology and Molecular Biology Reviews 70(4), 859-875 (2006). 2.Gould, T.A.,Herman, J.,Krank, J., et al. Specificity of acyl-homoserine lactone syntheses examined by mass spectrometry. Journal of Bacteriology 188(2), 773-783 (2006). 3.Geske, G.D.,ONeill, J.C. and Blackwell, H.E. N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in Vibrio fischeri. ACS Chemical Biology 2(5), 315-319 (2007). 4.Geske, G.D.,ONeill, J.C.,Miller, D.M., et al. Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing. ChemBioChem 9(3), 389-400 (2008). 5.Geske, G.D.,ONeill, J.C.,Miller, D.M., et al. Modulation of bacterial quorum sensing with synthetic ligands: Systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. Journal of the American Chemical Society 129, 13613-13625 (2007). 6.Geske, G.D.,Wezeman, R.J.,Siegel, A.P., et al. Small molecule inhibitors of bacterial quorum sensing and biofilm formation. Journal of the American Chemical Society 127(37), 12762-12763 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 219.2 |
| 分子式 | C12H13NO3 |
| CAS号 | 55154-48-8 |
| 稳定性 | ≥ 2 years |
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