KRN 633
货号：
14871-50mg 基本售价：
12012.0 元 规格：
50 mg
产品信息
概述| 货号 | 14871-50mg |
| 描述 | KRN 633 is an ATP-competitive inhibitor of VEGFR kinase activity (IC50s = 170, 160, and 125 nM for VEGFR1, 2, and 3, respectively).1 At higher concentrations KRN 633 inhibits PDGFR-α and c-KIT with IC50 values of 0.97 and 4.3 μM, respectively, and is inactive towards a panel of 17 additional kinases.1 KRN 633 suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fedorov, O.,Marsden, B.,Pogacic, V., et al. A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 104(51), 20523-20528 (2007).
2.Nakamura, K.,Yamamoto, A.,Kamishohara, M., et al. KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. Molecular Cancer Therapeutics 3(12), 1639-1649 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 416.9 |
| 分子式 | C20H21ClN4O4 |
| CAS号 | 286370-15-8 |
| 稳定性 | ≥ 2 years |
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