E-64d
货号：
13533-25mg 基本售价：
12012.0 元 规格：
25 mg
产品信息
概述| 货号 | 13533-25mg |
| 描述 | Cysteine proteases are a class of enzymes containing an active-site cysteine residue that is important in protein degradation pathways E-64d, a synthetic analog of E-64 and ethyl ester of E-64c, is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases.1 E-64d inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. By disrupting protease activity, E-64d, at concentrations between 20-200 µM, has been shown to arrest human epidermoid carcinoma A431 cells at mitotic metaphase.2 It also inhibits protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells with an IC50 value of 0.5 µM.3 |
| 别名 | Aloxistatin;E-64c ethyl ester;EP 453;EST;Loxistatin;NSC 694281; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wilcox, D. and Mason, R.W. Inhibition of cysteine proteinases in lysosomes and whole cells. Biochemistry Journal 285, 495-502 (1992).
2.Shoji, Y.,Senshu, M.,Iwashita, S., et al. Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase. Proceedings of the National Academy of Sciences of the United States of America 85, 146-150 (1988).
3.Doh-Ura, K.,Iwaki, T. and Caughey, B. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. Journal of Virology 74(10), 4894-4897 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 342.4 |
| 分子式 | C17H30N2O5 |
| CAS号 | 88321-09-9 |
| 稳定性 | ≥ 2 years |
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