AZD 8330
货号：
11588-50mg 基本售价：
12012.0 元 规格：
50 mg
产品信息
概述| 货号 | 11588-50mg |
| 描述 | AZD 8330 is a selective allosteric inhibitor of MEK1/2 (IC50 = 7 nM). It blocks phosphorylation of ERK1/2 and inhibits proliferation of certain cancer cells.1 AZD 8330 is orally bioavailable, inhibits ERK phosphorylation in vivo, and reduces tumor growth in a Calu-6 nude rat xenograft model.2 |
| 别名 | ARRY-424704; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baranski, Z.,Booij, T.H.,Kuijjer, M.L., et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer 6(11-12), 503-512 (2015).
2.Cohen, R.B.,Aamdal, S.,Nyakas, M., et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur. J. Cancer 49(7), 1521-1529 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 461.2 |
| 分子式 | C16H17FIN3O4 |
| CAS号 | 869357-68-6 |
| 稳定性 | ≥ 2 years |
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