E-64c
货号：
10007964-25mg 基本售价：
12012.0 元 规格：
25 mg
产品信息
概述| 货号 | 10007964-25mg |
| 描述 | Cysteine proteases are a class of enzymes containing an active-site cysteine residue that are important in protein degradation pathways. E-64c is a synthetic analog of E-64, a potent and irreversible cysteine protease inhibitor isolated from Aspergillusjaponicus.1 E-64c inhibits the cysteine proteases cathepsin B and cathepsin L from rat liver with IC50 values of 8.7 and 3.5 nM, respectively.2 The ethyl ester of E-64c, E-64d, is cell permeable and hydrolyzed in cell culture to E-64c. E-64d arrests the growth of A431 cells in metaphase at concentrations between 20-200 µg/ml.2 |
| 别名 | NSC 694279;Loxistatin Acid;EP 475; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Drahl, C.,Cravatt, B.F., and Sorensen, E.J. Protein-reactive natural products. Angewandte Chemie International Edition 44, 5788-5809 (2005).
2.Shoji, Y.,Senshu, M.,Iwashita, S., et al. Thiol protease-specific inhibitor E-64 arrests human epidermoid carcinoma A431 cells at mitotic metaphase. Proceedings of the National Academy of Sciences of the United States of America 85, 146-150 (1988).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 314.4 |
| 分子式 | C15H26N2O5 |
| CAS号 | 76684-89-4 |
| 稳定性 | ≥ 2 years |
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