| 货号 | 5177/50 |
| 别名 | N-3-[[5-Chloro-2-[[2-methoxy-4-(4-m |
| 供应商 | Tocris |
| 生物活性 | Potent and selective NUAK1/2 inhibitor (IC50 values are 20 and 100 nM respectively). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 496.99 |
| 分子式 | C25H29ClN6O3 |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 20 mM in DMSO with gentle warming |
| 参考文献 | Banerjeeet al (2014) Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase. Biochem.J. 461 233. PMID: 24785407. Banerjeeet al (2014) Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem.J. 457 215. PMID: 24171924. Zhouet al (2009) Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 462 1070. PMID: 20033049. |