| 货号 | 4216/50 |
| 别名 | (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3, |
| 供应商 | Tocris |
| 生物活性 | High affinity AT1 receptor antagonist (Ki = 2.38 nM). Displays 30,000-fold selectivity over AT2 receptors. Inhibits angiotensin II-induced release of aldosterone in vitro. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 435.52 |
| 分子式 | C24H29N5O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Hanafyet al (2008) Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers. Br.J.Pharmacol. 153 90. PMID: 17965735. Wexleret al (1996) Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J.Med.Chem. 39 625. PMID: 8576904. Criscioneet al (1993) Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype. Br.J.Pharmacol. 110 761. PMID: 8242249. |