| 货号 | 5088/50 |
| 别名 | N-[2-Chloro-5-[[[(3-chlorophenyl)me |
| 供应商 | Tocris |
| 生物活性 | Potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 498.32 |
| 分子式 | C23H17Cl2N5< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Andersonet al (2013) Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett. 15 6610. PMID: 24239188. Ewtonet al (2011) Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol.Cancer Ther. 10 2104. PMID: 21878655. |