| 货号 | 4154/50 |
| 别名 | 3-Chloro-4-fluoro-N-[4-[[2-(phenylc |
| 供应商 | Tocris |
| 生物活性 | NMDA receptor antagonist selective for NR1/NR2A over NR1/NR2B-containing receptors (pIC50 values are 6.8 and <4.3, respectively, in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca2+assays). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 461.89 |
| 分子式 | C21H17ClFN3O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Gipsonet al (2013) Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc.Natl.Acad.Sci.U S A [Epub ahead of print]. PMID: 23671067. Edmanet al (2012) TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology 63 441. PMID: 22579927. Hansenet al (2012) Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J.Neurosci. 32 6197. PMID: 22553026. Shinet al (2011) Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat. Br.J.Pharmacol. 166 1002. PMID: 22142193. Bettiniet al (2010) Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J.Pharm.Exp.Ther. 335 644. PMID: 20810618. |