TC-G 1008 (50 MG)
货号：
5355/50 基本售价：
11976.7 元 规格：
50 mg
产品信息
概述| 货号 | 5355/50 |
| 别名 | N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s >10μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s >30μM). Increases GLP-1 levels in vitroandin vivo. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 418.9 |
| 分子式 | C18H19ClN6O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Peukertet al (2014) Discovery of 2-pyridylpyrimidines as the first orally bioavailable GPR39 agonists. ACS Med.Chem.Lett. 5 1114. PMID: 25313322. |
