SR 2211 (50 MG)
货号：
4869/50 基本售价：
11976.7 元 规格：
50 mg
产品信息
概述| 货号 | 4869/50 |
| 别名 | 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol |
性能| 供应商 | Tocris |
| 生物活性 | Selective inverse agonist of retinoic acid receptor-related orphan receptor γ(RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α(LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 527.48 |
| 分子式 | C26H24F7N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| 参考文献 | Kumaret al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672. PMID: 22292739. |
