| 货号 | 5391/50 |
| 别名 | 1-(1-Methylethyl)-3-(2-phenylethyny |
| 供应商 | Tocris |
| 生物活性 | Potent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 277.32 |
| 分子式 | C16H15N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Dinéret al (2012) Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors. J.Med.Chem. 55 4872. PMID: 22559926. Kleinet al (2011) Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS ONE 6 e20789. PMID: 21698101. |