| 货号 | 4240/50 |
| 别名 | N3-[2-[[4-[Bis(4-chlorophenyl)methy |
| 供应商 | Tocris |
| 生物活性 | Restores mutant p53 activity. Binds p53 DNA binding domain (Kd = 1-2 μM) and restores wild-type function to many oncogenic mutants by acting as a chaperone. Inhibits ubiquitination of p53 by HDM2. Triggers apoptosis in tumor cell lines and reduces tumor growth in a xenograft model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 563.56 |
| 分子式 | C31H36Cl2N6< |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 10 mM in DMSO with sonication |
| 参考文献 | Essmann & Schulze-Osthoff (2012) Translational approaches targeting the p53 pathway for anti-cancer therapy. Br.J.Pharmacol. 165 328. PMID: 21718309. Demmaet al (2010) SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53. J.Biol.Chem. 285 10198. PMID: 20124408. |