| 货号 | 3571/50 |
| 别名 | 2-Bromo-N-[4-chloro-3-[[(3R)-1-meth |
| 供应商 | Tocris |
| 生物活性 | Selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively). Inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 505.81 |
| 分子式 | C19H22BrCIN2O5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 474960-44-6 |
| 参考文献 | Behmet al (2008) Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues. Br.J.Pharmacol. 155 374. PMID: 18587423. Douglaset al (2005) Nonpeptide urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Br.J.Pharmacol. 145 620. PMID: 15852036. |