| 货号 | 5315/50 |
| 别名 | 3β,5β,14β)-21,23-Epoxy-24-norchola-20, |
| 供应商 | Tocris |
| 生物活性 | Na+/K+ ATPase modulator. Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypersensitive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ATPaseα3 subunit mutation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 374.51 |
| 分子式 | C23H34O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Kirshenbaumet al (2011) Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPaseα3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 108 18144. PMID: 22025725. Ferrariet al (2010) Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 1802 1254. PMID: 20083196. Ferrari (2006) Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 290 529. PMID: 16467500. |