| 货号 | 5338/50 |
| 别名 | 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbony |
| 供应商 | Tocris |
| 生物活性 | Potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 468.59 |
| 分子式 | C29H32N4O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl with gentle warming |
| 参考文献 | Cotten (2013) TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth.Analg. 116 810. PMID: 23460565. Coburnet al (2012) Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem 7 123. PMID: 21916012. |