| 货号 | 5101/50 |
| 别名 | 7-(Benzoylamino)-4,9-dihydro-4-meth |
| 供应商 | Tocris |
| 生物活性 | A nonpeptide inhibitor of NGF binding to p75NTR(IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 362.34 |
| 分子式 | C19H14N4O4 |
| 可溶性/溶解性 | Soluble to 20 mM in 1eq. NaOH with sonication |
| 参考文献 | Eiblet al (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 61 1266. PMID: 23103525. Longoet al (2008) Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 7 63. PMID: 18289033. Colquhounet al (2004) Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 310 505. PMID: 15051797. |