| 货号 | 5012/50 |
| 别名 | 1-Cyclopentyl-3-(4-phenoxyphenyl)-1 |
| 供应商 | Tocris |
| 生物活性 | Potent BTK inhibitor (IC50 = 0.3 nM). Blocks B cell antigen receptor (BCR)-mediated gene expression in CD20+ B cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 371.44 |
| 分子式 | C22H21N5O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Krishnamurtyet al (2013) Active site profiling reveals coupling between domains in SRC-family kinases. Nat.Chem.Biol. 9 43. PMID: 23143416. Honigberget al (2010) The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc.Natl.Acad.Sci.U.S.A. 107 13075. PMID: 20615965. |