| 货号 | 5192/50 |
| 别名 | 1-(3,4-Dihydroxybenzoyl)-6,7-dihydr |
| 供应商 | Tocris |
| 生物活性 | High affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (Ki values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 341.27 |
| 分子式 | C17H11NO7 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Choiet al(2013)In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development. 140 660. PMID: 23293297. Chenet al (2001) Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J.Med.Chem. 44 4001. PMID: 11689087. |