| 货号 | 4299/50 |
| 别名 | 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Thought to directly influence the interaction between β-catenin and TCF4. Induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 375.44 |
| 分子式 | C21H17N3O2 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO |
| 参考文献 | Gonsalveset al (2011) An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc.Natl.Acad.Sci.USA 1085954. Watanabe and Dai (2011) Winning WNT: race to Wnt signaling inhibitors. Proc.Natl.Acad.Sci.USA 1085929. |