| 货号 | 4809/50 |
| 别名 | 6-Amino-2-(butylamino)-9-[[6-[2-(di |
| 供应商 | Tocris |
| 生物活性 | Potent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 400.48 |
| 分子式 | C19H28N8O2 |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO |
| 参考文献 | Adlardet al (2014) A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int.J.Cancer 135 820. PMID: 24390981. Nakamuraet al (2013) Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg.Med.Chem.Lett. 23 669. PMID: 23265901. |