| 货号 | 5417/50 |
| 别名 | N-[2-(Dimethylamino)ethyl]-12-oxo-1 |
| 供应商 | Tocris |
| 生物活性 | p53 pathway activator; induces expression of p53 target genes. Also RNA polymerase 1 inhibitor; promotes degradation of RPA194. Reduces viability of multiple tumor cell lines and attenuates tumor growth of A375 melanoma cell xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 360.41 |
| 分子式 | C21H20N4O2 |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO with gentle warming |
| 参考文献 | Coliset al (2014) Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J.Med.Chem. 57 4950. PMID: 24847734. Peltonenet al (2014) A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell 13 77. PMID: 24434211. Peltonenet al (2010) Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS ONE 5 e12996. PMID: 20885994. |