| 货号 | 4048/50 |
| 别名 | 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7- |
| 供应商 | Tocris |
| 生物活性 | Selective positive allosteric modulator of mGlu2(EC50 = 33.2 nM in CHO cells expressing human mGlu2). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 454.56 |
| 分子式 | C30H30O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Benneyworthet al (2007) A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol.Pharmacol. 72 477. PMID: 17526600. Galiciet al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J.Pharmacol.Exp.Ther. 318 173. PMID: 16608916. Bonnefouset al (2005) Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg.Med.Chem.Lett. 15 4354. PMID: 16046122. |