| 货号 | 1475/50 |
| 别名 | N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hy |
| 供应商 | Tocris |
| 生物活性 | Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at KV11.1 (hERG) channels (IC50 > 30 μM). Racemate Chromanol 293B (Cat. No. 1412) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 324.39 |
| 分子式 | C15H20N2O4S |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO with gentle warming |
| CAS号 | 163163-24-4 |
| 参考文献 | Lercheet al (2001) Molecular impact of MinK on the enantiospecific block of IKs by chromanols. Br.J.Pharmacol. 131 1503. PMID: 11139424. Seebohmet al (2001) A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B. Br.J.Pharmacol. 134 1647. PMID: 11739240. Yanget al (2000) Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 294 955. PMID: 10945846. |