| 货号 | 13740-10mg |
| 描述 | Butaprost, a structural analog of PGE2, is a selective agonist for the EP2 receptor subtype. EP2 receptors are expressed on human neutrophils and on respiratory, vascular, and uterine smooth muscle.1,2 Butaprost binds with about 1/10 the affinity of PGE2 to the recombinant murine EP2 receptor, and does not bind appreciably to any of the other murine EP receptors or DP, TP, FP, or IP receptors.3 The EC50 for the stimulation of cAMP by butaprost in COS cells transfected with the human EP2 receptor is about 5 µM, while the EC50 for PGE2 in this assay is about 43 nM.1 Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.4 Cayman Chemical is a leading manufacturer of prostaglandin products and is currently the sole supplier of butaprost. |
| 别名 | 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1 methyl ester;TR 4979; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Regan, J.W.,Bailey, T.J.,Pepperl, D.J., et al. Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. Molecular Pharmacology 46, 213-220 (1994). 2.Talpain, E.,Armstrong, R.A.,Coleman, R.A., et al. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils. British Journal of Pharmacology 114, 1459-1465 (1995). 3.Kiriyama, M.,Ushikubi, F.,Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British Journal of Pharmacology 122, 217-224 (1997). 4.Lawrence, R.A. and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. British Journal of Pharmacology 105, 817-824 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 408.6 |
| 分子式 | C24H40O5 |
| CAS号 | 69685-22-9 |
| 稳定性 | ≥ 2 years |
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