Agomelatine
货号：
13203-100mg 基本售价：
11956.0 元 规格：
100 mg
产品信息
概述| 货号 | 13203-100mg |
| 描述 | Melatonin, produced in the pineal gland, is an endogenous regulator of circadian rhythms. It acts through the melatonin receptors (MT1 and MT2) and has been shown to have anti-depressant activity in experimental models of clinical depression. Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity.1 However, unlike melatonin, agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).2 Agomelatine abolishes 5-HT2C agonist effects both in cells and in vivo. It also dose-dependently increases extracellular levels of noradrenaline and dopamine in frontal cortex of freely moving rats.2 |
| 别名 | Valdoxan®; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yous, S.,Andrieux, J.,Howell, H.E., et al. Novel naphthalenic ligands with high affinity for the melatonin receptor. Journal of Medicinal Chemistry 35(8), 1484-1486 (1992).
2.Millan, M.J.,Gobert, A.,Lejeune, F., et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. Journal of Pharmacology and Experimental Therapeutics 306(3), 954-964 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 243.3 |
| 分子式 | C15H17NO2 |
| CAS号 | 138112-76-2 |
| 稳定性 | ≥ 2 years |
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