| 货号 | 44570-250ug |
| 描述 | 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid.1,2 It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4(LTB4), and 5(S),12(S)-DiHETE.1 Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids.3 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction.4,5 It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons6 and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.7,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maclouf, J.,Fruteau De Laclos, B. and Borgeat, P. Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-eicosatetraenoic acid. Proceedings of the National Academy of Sciences of the United States of America 79, 6042-6046 (1982). 2.Kishimoto, K.,Nakamura, M.,Suzuki, H., et al. Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative. Biochimica et Biophysica Acta 1300, 56-62 (1996). 3.Pace-Asciak, C.R.,Granström, E. and Samuelsson, B. Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids. The Journal of Biological Chemisty 258, 6835-6840 (1983). 4.Nishiyama, M.,Okamoto, H.,Watanabe, T., et al. Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced vasoconstriction. European Journal of Pharmacology 341, 57-63 (1998). 5.Rao, G.N.,Glasgow, W.C.,Eling, T.E., et al. Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. The Journal of Biological Chemisty 271, 27760-27764 (1996). 6.Piomelli, D.,Volterra, A.,Dale, N., et al. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature 328, 38-43 (1987). 7.Piomelli, D.,Wang, J.K.T.,Sihra, T.S., et al. Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites. Proceedings of the National Academy of Sciences of the United States of America 86, 8550-8554 (1989). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 336.5 |
| 分子式 | C20H32O4 |
| CAS号 | 71774-10-2 |
| 稳定性 | ≥ 6 months |
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