| 货号 | 6053/50 |
| 别名 | 4-[6-[4-(1-Piperazinyl)phenyl]pyraz |
| 供应商 | Tocris |
| 生物活性 | Potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB 431542 (Cat. No. 1614). Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat. No. 1614), SU 5402 (Cat. No. 3300), CHIR 99021 (Cat. No. 4423) and DAPT (Cat. No. 2634). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 479.4 |
| 分子式 | C25H22N6.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 20 mM in DMSO |
| 参考文献 | Liet al (2013) Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell 13 270. PMID: 24012368. Chamberset al (2012) Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nat.Biotechnol. 30 715. PMID: 22750882. Cunyet al (2008) Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg.Med.Chem.Lett. 18 4388. PMID: 18621530. Yuet al (2008) BMP type I receptor inhibition reduces heterotopic ossification. Nat.Med. 14 1363. PMID: 19029982. |